Clincial Study Patient Recruitment and Site Engagement

Hepatitis C

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Making a difference in the lives of people with hepatitis C



IndicationHepatitis C


MaterialsPatient Outreach

 Patient Education

 Site Staff Materials

 Referring Physician

 Patient Retention

Chronic hepatitis C virus (HCV) infection afflicts more than 170 million people worldwide and is the major etiological cause of fibrosis, liver cirrhosis, and hepatocellular carcinoma. Current treatment relies on a backbone of interferon and ribavirin, a regimen with poor tolerability and toxicity. Efforts to develop novel therapies to improve treatment have focused largely on direct acting antiviral agents (DAAs) (19), which therapeutically intervene with virally encoded components essential for HCV replication.

This clinical study was conduscted to evaluate the efficacy and safety study of grazoprevir (MK-5172) in combination with elbasvir (MK-8742) with or without ribavirin (RBV) in participants with chronic hepatitis C virus (HCV) genotype (GT) 1, 4, or 6 infections who have failed prior therapy with pegylated interferon and RBV. The primary study hypothesis is that in at least one of the study arms, the percentage of participants achieving sustained viral response 12 weeks after the end of all study treatment (SVR12) will be superior to 58%.
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